Mid Atlantic Retina offices will be closed Nov 24th and 25th.

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Central Serous Chorioretinopathy

What is Central Serous Chorioretinopathy?

Fluorescein Angiogram showing leakage due to CSCR

Central serous chorioretinopathy (CSCR) is a condition that causes fluid to build up underneath the center of the retina (macula). Fluid leaks from a layer of blood vessels that run beneath the retina called the choroid. CSCR is more common in men, primarily between the ages of 25 to 50 years.

Most patients notice a central gray or blind spot in their vision. Objects often appear distorted and miniaturized, sometimes appearing farther away in the involved eye. Colors can appear washed out. Vision is rarely severely affected and most cases affect only one eye, but it can involve both eyes.

What causes CSCR?

The exact cause of CSCR remains unknown. However, corticosteroid use in any form (oral, topical, inhaled, or injected), stress, and “Type A” personality traits have been associated with CSCR. Those with a history of CSCR should avoid steroid medications if possible. Other associations include pregnancy, Cushing syndrome (an endocrine disorder with elevated cortisol levels), high blood pressure, organ transplantation, and lupus.

OCT image showing sub-retinal fluid due to CSCR

What is the follow-up and treatment?

In most cases, the fluid under the retina resolves spontaneously over several months and the final visual outcome is usually good, though not always perfect due to permanent damage to the retinal tissue. Given the favorable natural history of this condition, patients are usually followed initially without treatment. However, it is important to realize that CSCR is often a chronic disease. It may recur in 20-30% of patients and some degree of permanent visual loss is more likely in recurrent or prolonged cases.

Treatment may be recommended to promote resolution of the subretinal fluid if it has not reabsorbed after a few months. It may also be advised for recurrence in an eye with visual loss from a previous episode or if there is a need for prompt visual restoration such as for occupational reasons. Treatment options include thermal laser (“hot” laser), photodynamic therapy (“cool” laser), intraocular injection of Avastin, or oral mineralocorticoid receptor antagonists, such as eplerenone. If treatment is advised, your retina specialist will review the risks, benefits, and alternatives of the treatment options with you and make tailored recommendations based on the unique findings of your eye.


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Browse through the articles on this page to explore a wide range of topics related to retinal health. Visit other pages on our site, including our retinal disease page, for additional information as well.

Mid Atlantic Retina is made up of top Wills Eye Physicians, known for being the best retina doctors in the country. To seek further retina information and personalized care from a board-certified retinal specialist, make an appointment at one of our convenient locations in the Pennsylvania, Delaware, or the New Jersey area. Our specialists offer the most advanced treatments for adult and pediatric retinal diseases, and we pride ourselves on providing all of our patients with the highest level of care. This includes efficient diagnostics and the latest in treatments and procedures, with state-of-the-art services tailored to your needs.

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